A pH-independent electrochemical aptamer-based biosensor supports quantitative, real-time measurement <i>in vivo</i>
Shaoguang Li, Andrés Ferrer‐Ruiz, Jun Dai, Javier Ramos‐Soriano, Xuewei Du, Man Zhu, Wanxue Zhang, Yuanyuan Wang, M. Ángeles Herranz, Jing Le, Zishuo Zhang, Hui Li, Fan Xia, Nazario Martı́n
Abstract
An electrochemical aptamer-based sensor, enabling in vivo measurements of drug concentrations directly in the bladder of living rats under pH-variable conditions, was developed employing a π-extended tetrathiafulvalene (exTTF) as redox reported.
Topics & Concepts
AptamerBiosensorIn vivoChemistryElectrochemistryChromatographyCombinatorial chemistryAnalytical Chemistry (journal)BiophysicsNanotechnologyElectrodeMaterials scienceBiochemistryBiologyMolecular biologyPhysical chemistryBiotechnologyAdvanced biosensing and bioanalysis techniquesElectrochemical Analysis and ApplicationsAnalytical Chemistry and Sensors