Layered Chirality Relay Model in Rh(I)-Mediated Enantioselective C–Si Bond Activation: A Theoretical Study
Shihan Liu, Tao Zhang, Lei Zhu, Fenru Liu, Ruopeng Bai, Yu Lan
Abstract
A three-layer chirality relay model is proposed for Rh(I)-mediated enantioselective siletane activation. A chiral ligand in the back layer controls the position of the alkyne-coordinated metal center in the middle layer, which then provides a chiral environment for the incoming substrate at the front layer. A two-dimensional contour map analysis further clarified this model.
Topics & Concepts
Enantioselective synthesisChemistryChirality (physics)Layer (electronics)RelayAlkyneSubstrate (aquarium)StereochemistryRhodiumMetalCatalysisPhysicsChiral symmetryOrganic chemistryQuantum mechanicsQuarkPower (physics)GeologyNambu–Jona-Lasinio modelOceanographyCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistry