The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation
Larisa H. Cavallari, J. Kevin Hicks, Jai N. Patel, Amanda L. Elchynski, D. Max Smith, Salma A. Bargal, A. Fleck, Christina L. Aquilante, Shayna R. Killam, Lauren Lemke, Taichi Ochi, Laura B. Ramsey, Cyrine E. Haidar, Teresa Ho, Nihal El Rouby, Andrew A. Monte, Josiah D. Allen, Amber L. Beitelshees, Jeffrey R. Bishop, Chad Bousman, R. W. F. Campbell, Emily J. Cicali, Kelsey J. Cook, Benjamin Q. Duong, Evangelia Eirini Tsermpini, Sonya Tang Girdwood, David Gregornik, Kristin Grimsrud, Nathan Lamb, James C. Lee, Rocio Ortı́z-López, Tinashe Mazhindu, Sarah Morris, Mohamed Nagy, Jenny Nguyen, Amy L. Pasternak, Natasha Petry, Ron H. N. van Schaik, April Schultz, Todd C. Skaar, Hana Al Alshaykh, James M. Stevenson, Rachael M. Stone, Nam K. Tran, Sony Tuteja, Erica L. Woodahl, L. Yuan, Craig R. Lee
Abstract
Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual's genotype in conjunction with other important clinical factors. Despite significant evidence of genetic associations with drug response, pharmacogenetic testing has not been widely implemented into clinical practice. Among the barriers to broad implementation are limited guidance for how to successfully integrate testing into clinical workflows and limited data on outcomes with pharmacogenetic implementation in clinical practice. The Pharmacogenomics Global Research Network Implementation Working Group seeks to engage institutions globally that have implemented pharmacogenetic testing into clinical practice or are in the process or planning stages of implementing testing to collectively disseminate data on implementation strategies, metrics, and health-related outcomes with the use of genotype-guided drug therapy to ultimately help advance pharmacogenetic implementation. This paper describes the goals, structure, and initial projects of the group in addition to implementation priorities across sites and future collaborative opportunities.