Structural Insights into Microbial One-Carbon Metabolic Enzymes Ni–Fe–S-Dependent Carbon Monoxide Dehydrogenases and Acetyl-CoA Synthases
Alison Biester, Andrea N. Marcano-Delgado, Catherine L. Drennan
Abstract
and methane production. Here we review some of the recent advances in understanding the structure and mechanism of CODHs, CODH/ACSs, and ACDSs, their unusual metallocofactors, and their unique metabolic roles in the human gut and elsewhere.
Topics & Concepts
Carbon monoxide dehydrogenaseAcetyl-CoAChemistryCarbon monoxideEnzymeBiochemistryCarbon fibersCarbon fixationAcetogenesisCatalysisStereochemistryOrganic chemistryMethaneMethanogenesisMaterials sciencePhotosynthesisComposite numberComposite materialPorphyrin Metabolism and DisordersMetalloenzymes and iron-sulfur proteinsAnaerobic Digestion and Biogas Production