Rongalite-induced transition-metal and hydride-free reductive aldol reaction: a rapid access to 3,3′-disubstituted oxindoles and its mechanistic studies
Sivaparwathi Golla, Naveenkumar Anugu, Swathi Jalagam, Hari Prasad Kokatla
Abstract
A rongalite-induced transition-metal and hydride-free reductive aldol reaction has been developed for the synthesis of 3,3′-disubstituted oxindoles. In this method, rongalite plays a vital role as a reducing agent and a source of the C1 unit.
Topics & Concepts
Aldol reactionHydrideCombinatorial chemistryChemistryTransition metalReductive eliminationMetalOrganic chemistryCatalysisAsymmetric Synthesis and CatalysisAlkaloids: synthesis and pharmacologyChemical Synthesis and Reactions