Sulfonium Salt-Mediated Difunctionalization of Alkynes for Access to <i>Z</i>-Alkenyl Phosphorothioates and Selenophosphates
Sha Peng, Xinhua Xu, Li Tang, Ni-Dan Meng, Li‐Hua Yang, Long‐Yong Xie
Abstract
In this work, we present a practical and efficient one-pot sulfonium salt-mediated difunctionalization reaction of alkynes. This method facilitates the diverse synthesis of various alkenyl phosphorthioates and selenophosphates in acceptable yields. Importantly, the reaction is completely regio- and stereoselective, producing absolutely Z -configured alkenylated phosphorothioates and selenophosphates with a broad substrate scope and high functional group tolerance.
Topics & Concepts
SulfoniumChemistryStereoselectivityScope (computer science)Salt (chemistry)Substrate (aquarium)Combinatorial chemistryReaction conditionsStereochemistryOrganic chemistryCatalysisProgramming languageOceanographyComputer scienceGeologySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods