Metformin mitigates stress-induced premature senescence by upregulating AMPKα at Ser485 phosphorylation induced SIRT3 expression and inactivating mitochondrial oxidants
Jin Young Sung, Seul Gi Kim, Young Jin Kang, Hyoung Chul Choi
Topics & Concepts
SOD2SenescenceSIRT3MetforminAMPKOxidative stressMitochondrial ROSReactive oxygen speciesMitochondrionAMP-activated protein kinaseEndocrinologyCell biologyBiologyInternal medicineChemistrySuperoxide dismutaseAcetylationPhosphorylationMedicineProtein kinase ASirtuinBiochemistryInsulinGeneSirtuins and Resveratrol in MedicineTelomeres, Telomerase, and SenescenceGenomics, phytochemicals, and oxidative stress