Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates
Timo von Keutz, David Cantillo, C. Oliver Kappe
Abstract
The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the reaction can be tuned by simply using either a basic or an acidic quench. Very good to excellent isolated yields, up to 97%, have been obtained for most cases (30 examples).
Topics & Concepts
ChemistryContinuous flowFlash (photography)Residence time (fluid dynamics)Continuous reactorReaction conditionsChlorideOrganic chemistryFlow chemistryCombinatorial chemistryComputational chemistryCatalysisBiochemical engineeringVisual artsArtGeotechnical engineeringEngineeringInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis