Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing
Francisco Olivença, Alexandra Nunes, Rita Macedo, David Pires, Cátia Silveiro, Elsa Anes, Maria Miragaia, João Paulo Gomes, Maria João Catalão
Abstract
or genes encoding canonical beta-lactam targets, such as peptidoglycan transpeptidases, are infrequent and do not greatly impact the MICs of potent carbapenem plus clavulanic acid combinations. An improved understanding of the global effect of cumulative mutations in relevant gene sets for peptidoglycan and cell division processes on beta-lactam susceptibility is also provided.
Topics & Concepts
Mycobacterium tuberculosisBiologyTuberculosisDrug resistanceMicrobiologyGeneGenomeGeneticsMedicinePathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisAntibiotic Resistance in Bacteria