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Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway

Bo Huang, Yufeng Qian, Shujun Xie, Xianhua Ye, Hanwen Chen, Zhifeng Chen, Lihuan Zhang, Jinming Xu, Hu Hu, Shenglin Ma, Paul Héroux, Di Wang, Han‐Ming Shen, Yihua Wu, Dajing Xia

2020Cellular and Molecular Immunology71 citationsDOIOpen Access PDF

Topics & Concepts

TicagrelorInflammasomeP2Y12PharmacologyInnate immune systemMedicinePlatelet activationSignal transductionInflammationImmune systemChemistryImmunologyAcute coronary syndromePlateletInternal medicineMyocardial infarctionBiochemistryPlatelet aggregationInflammasome and immune disordersKawasaki Disease and Coronary ComplicationsAdenosine and Purinergic Signaling
Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway | Litcius