Injectable microfluidic hydrogel microspheres based on chitosan and poly(ethylene glycol) diacrylate (PEGDA) as chondrocyte carriers
Lin Lin, Yanfang Wang, Ling Wang, Jianying Pan, Yichao Xu, Shiyu Li, Da Huang, Jiali Chen, Zilu Liang, Panjing Yin, Yanbin Li, Hongwu Zhang, Yaobin Wu, Chun Zeng, Wenhua Huang
Abstract
investigation further demonstrated that chondrocyte-laden CP-MSs were injectable and the cell viability was still high after injection. In particular, these cell-laden microspheres were self-assembled into a 3D cartilage-like scaffold by a bottom-up strategy based on cell-cell interconnectivity, which suggested that these injectable chondrocyte-laden microspheres showed potential applications as chondrocyte carriers for bottom-to-up cartilage tissue engineering.
Topics & Concepts
ChondrocyteEthylene glycolChitosanViability assayBiomedical engineeringMaterials scienceCartilageScaffoldInterconnectivityChemistryTissue engineeringCellNanotechnologyChemical engineeringAnatomyMedicineBiochemistryOrganic chemistryArtificial intelligenceEngineeringComputer scienceOsteoarthritis Treatment and MechanismsSilk-based biomaterials and applicationsHydrogels: synthesis, properties, applications