A concise metal-free synthesis of xanthene derivatives mediated by achiral 2-aminophenol under solvent-free conditions
Mohinuddin Khan Imon, Readul Islam, Pran Gopal Karmaker, Pijush Kanti Roy, Kee‐In Lee, H. N. Roy
Abstract
An efficient green technique has been developed for the synthesis of some biologically active 12-aryl or 12-alkyl 8,9,10,12-tetrahydrobenzo[a]xanthenes-11-one and 3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives have been described. This process arranged a three-component one-pot condensation of aldehydes, 2-naphthol, and dimedone mediated by 2-aminophenol and has offered an excellent scope of tailoring a large number of xanthene derivatives with good to charming yields. Short reaction time, straightforward, easy product isolation technique, non-toxic catalyst, and above all metal-free process are noteworthy advantages of this method.