Past, Present, and a Glance into the Future of Multiple Myeloma Treatment
Weam Othman Elbezanti, Kishore B. Challagundla, Subash C. Jonnalagadda, Tülin Budak-Alpdoǧan, Manoj K. Pandey
Abstract
Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for future treatments.
Topics & Concepts
Multiple myelomaMedicineBone marrowOverall survivalOncologyCancerCancer researchInternal medicineMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsCancer Mechanisms and Therapy