Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway
Demei Huang, Zherui Shen, Sijing Zhao, Caixia Pei, Nan Jia, Yilan Wang, Yongcan Wu, Xiaomin Wang, Shihua Shi, Yacong He, Zhenxing Wang, Fei Wang, Zhenxing Wang, Fei Wang
Topics & Concepts
PyroptosisInflammasomeProtein kinase BPharmacologyPI3K/AKT/mTOR pathwayChemistryToxicityProinflammatory cytokineInflammationPhosphorylationMedicineApoptosisImmunologyBiochemistryOrganic chemistryInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideChronic Obstructive Pulmonary Disease (COPD) Research