Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8 <sup>+</sup> T cell response in tumor
Yuan Wang, Xinting Wang, Xiaoteng Cui, Yue Zhuo, Hongshuai Li, Chuanbo Ha, Lingbiao Xin, Yuanyuan Ren, Wei Zhang, Xiaoming Sun, Lin Ge, Xin Liu, Jinyan He, Tao Zhang, Kai Zhang, Zhi Yao, Xi Yang, Jie Yang
Abstract
T cells both in vivo and in vitro. These findings reveal SND1 as a novel ER-associated protein facilitating immune evasion of tumor cells through redirecting HC to ERAD pathway that consequently interrupts antigen presentation.
Topics & Concepts
Cytotoxic T cellAntigen presentationEndoplasmic reticulumCD8Cell biologyMHC class IEndoplasmic-reticulum-associated protein degradationChemistryMajor histocompatibility complexAntigenImmune systemCancer researchBiologyUnfolded protein responseImmunologyBiochemistryIn vitroCancer Mechanisms and TherapyPhagocytosis and Immune RegulationComplement system in diseases