Role of ferroptosis in colorectal cancer
Yaqi Song, Xiaodan Yan, Yi Wang, Zhenzhen Wang, Xin‐Li Mao, Liping Ye, Shao-wei Li
Abstract
Colorectal cancer (CRC) is the second deadliest cancer and the third-most common malignancy in the world. Surgery, chemotherapy, and targeted therapy have been widely used to treat CRC, but some patients still develop resistance to these treatments. Ferroptosis is a novel non-apoptotic form of cell death. It is an iron-dependent non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species and has been suggested to play a role in reversing resistance to anticancer drugs. This review summarizes recent advances in the prognostic role of ferroptosis in CRC and the mechanism of action in CRC.
Topics & Concepts
MedicineColorectal cancerMalignancyCancerCancer researchCause of deathApoptosisChemotherapyReactive oxygen speciesProgrammed cell deathCauses of cancerOncologyInternal medicineDiseaseBiochemistryChemistryFerroptosis and cancer prognosisCancer, Lipids, and MetabolismDrug Transport and Resistance Mechanisms