Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci
Lin Zeng, Alejandro R. Walker, Robert A. Burne, Zachary A. Taylor
Abstract
mutants engineered in three different oral streptococci displayed altered capacities for acid production and interspecies antagonism, highlighting the potential for targeting the glucose-PTS to modulate the pathogenicity of oral biofilms.
Topics & Concepts
BiologyStreptococcus gordoniiPEP group translocationMicrobiologyMicrobial metabolismMicrobial ecologyBacteriaMicrobiomeStreptococcus sanguinisOral MicrobiomeCarbohydrate metabolismMetabolismStreptococcusBiochemistryBiofilmPhosphoenolpyruvate carboxykinaseEnzymeBioinformaticsGeneticsOral microbiology and periodontitis researchGenomics and Phylogenetic StudiesGut microbiota and health