Inhibiting Fibroblast Mechanotransduction Modulates Severity of Idiopathic Pulmonary Fibrosis
Artem A. Trotsyuk, Kellen Chen, Sun Hyung, Kun Ma, Dominic Henn, Alana M. Mermin-Bunnell, Smiti Mittal, Jagannath Padmanabhan, Madelyn R. Larson, Sydney R. Steele, Dharshan Sivaraj, Clark A. Bonham, Chikage Noishiki, Mélanie Rodrigues, Yuanwen Jiang, Serena L. Jing, Simiao Niu, Arhana Chattopadhyay, David Perrault, Melissa C. Leeolou, Katharina S. Fischer, Gurupranav Gurusankar, Hudson C. Kussie, Derrick C. Wan, Michael Januszyk, Michael T. Longaker, Geoffrey C. Gurtner
Abstract
Objective: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that affects 63 in every 100,000 Americans. Its etiology remains unknown, although inflammatory pathways appear to be important. Given the dynamic environment of the lung, we examined the significance of mechanotransduction on both inflammatory and fibrotic signaling during IPF.