Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis
Dan Yi, Dongxin Zhang, Jie He
Abstract
. LIFR-AS1 and SIDT2 expressions were suppressed in PTC tissues, while that of miR-31-5p was elevated in PTC tissues. LIFR-AS1 was negatively correlated with miR-31-5p. LIFR-AS1 sponged miR-31-5p to upregulate SIDT2, thereby inhibiting the viability, proliferation, migration, invasion, and the secretion of vascular endothelial growth factor (VEGF) of PTC cells and angiogenesis of human umbilical vein endothelial cells (HUVECs). This paper demonstrates that LIFR-AS1/miR-31-5p/SIDT2 axis modulated the development of PTC.
Topics & Concepts
Leukemia inhibitory factor receptorBiologyCancer researchGene silencingAngiogenesisLong non-coding RNADownregulation and upregulationCarcinogenesisMolecular biologyCancerImmunologyGeneBiochemistryInterleukin 6Leukemia inhibitory factorGeneticsCytokineCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing