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Development of KSQ-4279 as a first-in-class USP1 inhibitor for the treatment of BRCA-deficient cancers

Louise Cadzow, J. Brenneman, Richard Sullivan, H. Liu, Sol Shenker, Michael McGuire, Paula Grasberger, Kerstin W. Sinkevicius, Nafeeza Hafeez, Gavin Histen, Edmond Chipumuro, Julie A. Hixon, Elizabeth A. Krall, Shawn Cogan, Johannes H.W. de Wilt, Michael R. Schlabach, Frank Stegmeier, Andrew Olaharski, Andrew A. Wylie

2020European Journal of Cancer25 citationsDOI

Topics & Concepts

Poly ADP ribose polymerasePARP inhibitorHomologous recombinationPolymeraseCancer researchMedicineBiologyGeneticsGenePARP inhibition in cancer therapyDNA Repair MechanismsBRCA gene mutations in cancer
Development of KSQ-4279 as a first-in-class USP1 inhibitor for the treatment of BRCA-deficient cancers | Litcius