Development of KSQ-4279 as a first-in-class USP1 inhibitor for the treatment of BRCA-deficient cancers
Louise Cadzow, J. Brenneman, Richard Sullivan, H. Liu, Sol Shenker, Michael McGuire, Paula Grasberger, Kerstin W. Sinkevicius, Nafeeza Hafeez, Gavin Histen, Edmond Chipumuro, Julie A. Hixon, Elizabeth A. Krall, Shawn Cogan, Johannes H.W. de Wilt, Michael R. Schlabach, Frank Stegmeier, Andrew Olaharski, Andrew A. Wylie
Topics & Concepts
Poly ADP ribose polymerasePARP inhibitorHomologous recombinationPolymeraseCancer researchMedicineBiologyGeneticsGenePARP inhibition in cancer therapyDNA Repair MechanismsBRCA gene mutations in cancer