Litcius/Paper detail

<i>Sargassum fusiforme</i> fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis

Ya Zhang, Jian Liu, Genxiang Mao, Jihui Zuo, Shijun Li, Yue Yang, Ronald W. Thring, Mingjiang Wu, Haibin Tong

2021Food & Function23 citationsDOI

Abstract

Sargassum fusiforme fucoidan (SFF) remodels gut microbiota, enhances TUDCA content, inhibits the biosynthesis of colon-derived ceramide by blocking FXR signaling, restoring insulin sensitivity in DIO mice.

Topics & Concepts

FucoidanCeramideSargassumInsulin resistanceChemistryBiosynthesisBiochemistryBiologyEndocrinologyInsulinPolysaccharideBotanyGeneAlgaeApoptosisSeaweed-derived Bioactive CompoundsPhytoestrogen effects and researchDiet, Metabolism, and Disease