Lichen planus pemphigoides: A unique form of bullous and lichenoid eruptions secondary to nivolumab
Rohan Shah, Chinmoy Bhate, Amanda Hernandez, Chin Hung Ho
Abstract
The widespread use of PD-1 inhibitors to treat various solid tumors has brought certain challenges for the clinician, including immune-related adverse events (irAEs). Cutaneous toxicities are among the most observed irAEs. Bullous and lichenoid dermatoses following PD-1 inhibitor therapy have been described. Here we report a novel case of lichen planus pemphigoides, featuring characteristics of both bullous pemphigoid and lichen planus, in a patient treated with nivolumab for renal cell carcinoma. We subsequently review all three cutaneous conditions which may arise in the context of PD-1 inhibitor therapy.
Topics & Concepts
MedicineBullous pemphigoidDermatologyNivolumabContext (archaeology)Adverse effectImmunotherapyImmune systemImmunologyInternal medicineAntibodyPaleontologyBiologyAutoimmune Bullous Skin DiseasesOral Health Pathology and TreatmentCutaneous lymphoproliferative disorders research