Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models
Baljit Kaur, Hossam Nada, Longfei Zhang, Moustafa T. Gabr
Topics & Concepts
ChemistryPharmacokineticsSpheroidGlioblastomaPharmacologyCancer researchIn vitroBiochemistryBiologyMedicineRNA Interference and Gene DeliveryHistone Deacetylase Inhibitors ResearchMicroRNA in disease regulation