Role of acute exacerbations in skeletal muscle impairment in COPD
Harry R. Gosker, Ramon Langen, Sami O. Simons
Abstract
: The contribution of AECOPD and its recurrent nature to muscle impairment in COPD cannot be ignored and can be attributed to the acutely intensifying and converging disease-related drivers of muscle deterioration, in particular disuse, systemic inflammation and corticosteroid treatment. The search for novel treatment options should focus on the AECOPD-enhanced drivers of muscle dysfunction as well as on the underlying, mainly catabolic, mechanisms. Considering the impact of AECOPD on muscle function, and that of muscle impairment on the recurrence of exacerbations, counteracting muscle deterioration in AECOPD provides an unprecedented therapeutic opportunity.
Topics & Concepts
MedicineCOPDIntensive care medicineDiseasePulmonary diseaseQuality of life (healthcare)Skeletal musclePhysical therapyInternal medicineNursingChronic Obstructive Pulmonary Disease (COPD) ResearchNutrition and Health in AgingRespiratory Support and Mechanisms