Engineering robust microorganisms for organic acid production
Vinh Tran, Huimin Zhao
Abstract
Organic acids are an important class of compounds that can be produced by microbial conversion of renewable feedstocks and have huge demands and broad applications in food, chemical, and pharmaceutical industries. An economically viable fermentation process for production of organic acids requires robust microbial cell factories with excellent tolerance to low pH conditions, high concentrations of organic acids, and lignocellulosic inhibitors. In this review, we summarize various strategies to engineer robust microorganisms for organic acid production and highlight their applications in a few recent examples.
Topics & Concepts
Biochemical engineeringMicroorganismFermentationOrganic acidBiotechnologyProduction (economics)Renewable resourceEnvironmental sciencePulp and paper industryChemistryRenewable energyOrganic chemistryBacteriaBiologyEngineeringGeneticsMacroeconomicsEconomicsEcologyMicrobial Metabolic Engineering and BioproductionBiofuel production and bioconversionEnzyme Catalysis and Immobilization