MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience
Yoichi Muramoto, Naoya Murakami, Tatsuki Karino, Satoru Sugimoto, Jun Takatsu, Masaki Oshima, Yasuo Kosugi, Terufumi Kawamoto, Takashi Hirayama, Kazunari Fujino, Yasuhisa Terao, Naoto Shikama
Abstract
We first used MucoUp®, a hyaluronic acid used in endoscopic resection, as a spacer in brachytherapy. In five cervical cancer patients, MucoUp® insertion increased a 90% dose of the high-risk CTV to over 80 Gy while decreasing the dose of organs at risk. No related adverse events were observed.
Topics & Concepts
BrachytherapyMedicineCervical cancerAdverse effectRadiation therapyGynecologic cancerUterine cancerResectionRadiologyCancerGynecologySurgeryInternal medicineOvarian cancerEndometrial and Cervical Cancer TreatmentsAngiogenesis and VEGF in CancerUterine Myomas and Treatments