Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy
Dorian Forte, María García‐Fernández, Abel Sánchez‐Aguilera, Vaia Stavropoulou, Claire Fielding, Daniel Martín-Pérez, Juan Antonio López, Ana S.H. Costa, Laura Tronci, Efterpi Nikitopoulou, M. Barber, Paolo Gallipoli, Ludovica Marando, Carlos L.F. de Castillejo, Alexandar Tzankov, Sabine Dietmann, Michèle Cavo, Lucia Catani, Antonio Curti, Jesús Vázquez, Christian Frezza, Brian J.P. Huntly, Juerg Schwaller, Simón Méndez‐Ferrer
Abstract
BMSCs support survival and chemotherapy relapse of AML through increased oxidative phosphorylation, tricarboxylic acid (TCA) cycle activity, and glutathione (GSH)-mediated antioxidant defense. Therefore, AML cells co-opt energy sources and antioxidant defense mechanisms from BMSCs to survive chemotherapy.
Topics & Concepts
HaematopoiesisBone marrowStem cellBioenergeticsMyeloid leukemiaNestinCancer researchMesenchymal stem cellBiologyCell biologyHematopoietic stem cellImmunologyMitochondrionNeural stem cellHematopoietic Stem Cell TransplantationAcute Myeloid Leukemia ResearchMesenchymal stem cell research