Endoscopic ultrasound-guided sampling and profiling of portal circulation in human patients for metabolic research studies and biomarker assessment
Marvin Ryou, Nicholas Stylopoulos
2020American Journal of Physiology-Gastrointestinal and Liver Physiology18 citationsDOIOpen Access PDF
Abstract
The technical aspects, feasibility, and safety of endoscopic ultrasound (EUS)-guided needle access for portal venous blood collection are presented in this technical report. Despite the very small diameter of the endoscopic needle, portal blood samples have the same quality as those collected from systemic circulation. As a proof of the concept and the utility of this technique in metabolic research and biomarker assessment and discovery, we present a pilot metabolite profiling study of portal venous blood in a small cohort of patients with cirrhosis and a comparison with a group without cirrhosis.
Topics & Concepts
MedicineCirrhosisEndoscopic ultrasoundPortal hypertensionRadiologyPortal venous pressureHepatocellular carcinomaMalignancyInternal medicineGastroenterologyLiver Disease Diagnosis and TreatmentLiver Disease and TransplantationHepatocellular Carcinoma Treatment and Prognosis