Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine cinnamyl derivatives as inhibitors of FAK with potent anti-gastric cancer activities
Yang Liu, Lijun Kong, Na Li, Yunhe Liu, Mei-Qi Jia, Qiu-Ge Liu, Sai‐Yang Zhang, Jian Song
Topics & Concepts
ChemistryIC50Docking (animal)ApoptosisCancer cellProtein kinase BEnzymePotencyMAPK/ERK pathwayCancer researchSignal transductionBiochemistryCancerStereochemistryIn vitroBiologyGeneticsNursingMedicineCell Adhesion Molecules ResearchProtease and Inhibitor MechanismsUbiquitin and proteasome pathways