Cas9 activates the p53 pathway and selects for p53-inactivating mutations
Oana M. Enache, Verónica Rendo, Mai Abdusamad, Daniel D. Lam, Desiree Davison, Sangita Pal, Naomi Currimjee, Julian M. Hess, Sasha Pantel, Anwesha Nag, Aaron R. Thorner, John G. Doench, Francisca Vázquez, Rameen Beroukhim, Todd R. Golub, Uri Ben‐David
Topics & Concepts
CRISPRBiologyCas9Genome editingMutantCell cultureGeneGeneticsMutationCell biologyMolecular biologyCRISPR and Genetic EngineeringVirus-based gene therapy researchPluripotent Stem Cells Research