PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation
Zhouyangfan Peng, Xiqing Tan, Liangpeng Xie, Ze Li, Sufang Zhou, Yapei Li
Abstract
or palmitic acid-induced endothelial cell hyperactivation, IL-1β and HMGB1 release and co-cultured VSMC phenotype transforming. These results demonstrate that endothelial PKR activation induces GSDMD-mediated endothelial cell hyperactivation to release HMGB1 and IL-1β, which promotes the phenotype transforming of VSMC and subsequent accelerates the process of vascular aging. These discoveries will help to explore the new drug target to inhibit vascular aging.
Topics & Concepts
HyperactivationVascular smooth muscleCell biologyEndothelial stem cellBiologyCellCancer researchChemistryEndocrinologyInternal medicineIn vitroMedicineBiochemistrySmooth muscleRNA regulation and diseaseRNA modifications and cancerinterferon and immune responses