Circadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease

Abstract

We examined whether obesity and metabolic syndrome underlie the development of cardiac dysfunction in circadian mutant Clock Δ19/Δ19 mice. Surprisingly, we demonstrate that although Clock Δ19/Δ19 mice develop metabolic dysfunction, they are protected from cardiac hypertrophy, left ventricular remodeling, and diastolic dysfunction, in contrast to wild-type controls, even when challenged with a chronic high-fat diet. These findings shed new light on the circadian regulation of oxidative stress pathways that can mediate resilience to cardiovascular disease.

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