Base-Promoted, Metal- and Oxidant-Free C=C Bond Cleavage in Enaminones for Ambient Synthesis of NH<sub>2</sub>-Amidines
Guodong Wang, Yanhui Guo, Jie‐Ping Wan
Abstract
报道了室温条件下烯胺酮和磺酰叠氮通过碳-碳双键断裂合成N-磺酰基醚类化合物的方法.反应在1，8-二氮杂双环[5.4.0]十一碳-7-烯（DBU）存在下进行，无需使用任何金属和氧化剂，具有良好的底物适用性.烯胺酮上的15N同位素标记实验证实，磺酰叠氮仅作为产物中的磺酰胺片段供体，同时，该实验也有力地支持反应机理涉及关键的1，2，3-三唑啉中间体的原位形成以及环分解.
Topics & Concepts
ChemistryCleavage (geology)Bond cleavageMetalBase (topology)Medicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisFracture (geology)MathematicsEngineeringGeotechnical engineeringMathematical analysisChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisQuinazolinone synthesis and applications