The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction
Yue Zhao, Liu‐Xia Zhang, Ting Jiang, Jing Long, Zhong-Ye Ma, Aiping Lü, Yan Cheng, Dongsheng Cao
Topics & Concepts
PARP1OlaparibPoly ADP ribose polymeraseDNA damageDNA repairSynthetic lethalityCancer researchPolymeraseChemistryBiologyDNABiochemistryPARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisCell death mechanisms and regulation