Branched-chain amino acids alter cellular redox to induce lipid oxidation and reduce de novo lipogenesis in the liver
Chaitra Surugihalli, Vaishna Muralidaran, Caitlin E. Ryan, Kruti Patel, David Zhao, Nishanth E. Sunny
Abstract
Branched-chain amino acids (BCAAs) have been shown to modulate lipid metabolic networks in various tissues, especially during insulin resistance. In this study we show that the dietary supplementation of BCAAs to normal, insulin-sensitive mice resulted in higher mitochondrial NADH:NAD + ratios and AMPK activation in the liver. This change in the cellular redox status provided an optimal metabolic milieu to increase fatty acid oxidation while keeping the rates of de novo lipogenesis lower in the BCAA-supplemented mice livers.
Topics & Concepts
LipogenesisKetogenesisInternal medicineEndocrinologyLipid metabolismInsulin resistanceCatabolismBeta oxidationChemistryLipid oxidationMetabolismAMPKOxidative phosphorylationInsulinKetone bodiesBiologyBiochemistryPhosphorylationMedicineAntioxidantProtein kinase AMetabolomics and Mass Spectrometry StudiesLiver Disease Diagnosis and TreatmentAdipose Tissue and Metabolism