Gold(I)-Catalyzed Cycloisomerization–Indole Addition Cascade: Synthesis of 3(2<i>H</i>)-Furanone-Incorporated Unsymmetrical 3,3′- Bis(indolyl)methanes

Abstract

An unprecedented Au(I)-catalyzed domino intramolecular carbonyl-alkyne cyclization/indole addition strategy has been disclosed here. This generalized strategy enables the synthesis of 3(2H)-furanone-incorporated unsymmetrical bis(indolyl)methanes with generation of a stereocenter at the furanone junction from easily accessible indole-tethered ynediones. In addition, this present protocol could also be extended for the synthesis of a number of indolyl-(hetero)arylmethanes by employing a variety of (hetero)arenes as a nucleophile coupling partner.

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