Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and <i>in vivo</i> antitumor efficacy of Hexylselen
Jinzhang Fang, Zhao Chen, Jun Song, Jinxiu Li, Yunying Han, Wei Hou, Wenxi Wang, Benfang Helen Ruan
Abstract
antitumor efficacy of CPD-3B@SOL micelles in the H22 hepatocarcinoma xenograft mouse model. Thus, the current study provided a practical delivery system for allosteric inhibitors of glutaminase, which is one of the bottlenecks of targeting tumor glutaminolysis.
Topics & Concepts
GlutaminolysisAllosteric regulationIn vivoMicelleChemistryBioavailabilityDrug deliveryGlutaminaseSolubilityPharmacologyBiophysicsBiochemistryEnzymeGlutamineOrganic chemistryBiologyAqueous solutionGlycolysisAmino acidBiotechnologyCancer, Hypoxia, and MetabolismCancer Research and TreatmentsPancreatic function and diabetes