An endoplasmic reticulum-targeting hydroxyl radical fluorescent probe for imaging of ferroptosis and screening of natural protectants
Hongyu Li, Xue Luo, Yue Jian, Jiajia Lv, Xinmin Li, Jie Gao, Wen Shi, Xiaohua Li, Zeli Yuan, Huimin Ma
Abstract
imaging of ˙OH in a mouse tumor model. This work provides not only a new tool for ferroptosis monitoring but also a direct insight into the regulation mechanism of ferroptosis and development of new drugs for ferroptosis-related diseases.
Topics & Concepts
Endoplasmic reticulumFluorescenceChemistryHydroxyl radicalPhotochemistryBiophysicsRadicalBiochemistryBiologyQuantum mechanicsPhysicsRNA modifications and cancerFerroptosis and cancer prognosisinterferon and immune responses