Multifaceted roles of microbiota-derived deoxycholic acid in gastrointestinal cancers: from barrier disruption to therapeutic implications
Hai Zhao, Fan Yang, Jiaxin Yang, Sheng Yang
Topics & Concepts
TransactivationDeoxycholic acidChemistryCell biologyDNA damageTranscription factorEpidermal growth factor receptorSignal transductionLithocholic acidEpidermal growth factorReactive oxygen speciesMAPK/ERK pathwayCytokineCancer researchBiochemistryBiologyLipoteichoic acidBile acidReceptorCarcinogenesisBarrier functionCalcitriol receptorPharmacologyProinflammatory cytokineNitric oxideTumor necrosis factor alphaGastrointestinal epitheliumHelicobacter pylori-related gastroenterology studiesGut microbiota and healthDrug Transport and Resistance Mechanisms