Comparison of three biopsy forceps for hysteroscopic endometrial biopsy in postmenopausal patients (HYGREB‐1): A multicenter, single‐blind randomized clinical trial
Salvatore Giovanni Vitale, Antonio Simone Laganà, Salvatore Caruso, Simone Garzon, Giada Maria Vecchio, Valentina Lucia La Rosa, Jvan Casarin, Fabio Ghezzi
Abstract
OBJECTIVE: To compare three types of biopsy forceps for hysteroscopic endometrial biopsy in postmenopausal women. METHODS: Postmenopausal women undergoing operative hysteroscopy with endometrial biopsy for abnormal uterine bleeding or endometrial thickness (≥5 mm) were included. Operative hysteroscopy with endometrial biopsy was performed by hysteroscopic forceps. Women were randomized (1:1:1 ratio) in three groups and allocated to undergo endometrial biopsy by hysteroscopy using spoon, alligator, or snake forceps. RESULTS: Seventy-five women were included in the study, 25 in each group. The duration of the biopsy was comparable between the three groups (P = 0.334) with a median of 180 seconds (range 20-480 seconds). No differences were observed about the number of attempts (P = 0.602), the use of another instrument (P = 0.276), and the biopsy appropriateness (P = 0.592). The spoon forceps group reported higher levels of pain compared to the alligator and snake forceps groups (P < 0.001). The spoon forceps received significantly lower scores by the operator compared to the alligator and snake forceps (P < 0.001). The alligator and snake forceps reported wider biopsy than the spoon forceps (P < 0.001). CONCLUSION: Snake and alligator hysteroscopic forceps may be considered the first choice to perform an endometrial biopsy in postmenopausal women. ClinicalTrials.gov: NCT03427957.