Selective <i>N</i>-α-C–H alkylation of cyclic tertiary amides <i>via</i> visible-light-mediated 1,5-hydrogen atom transfer
Junlei Wang, Qinglin Xie, Guocheng Gao, Hongqing Li, Wenyun Lu, Xiaodong Cai, Xue‐Mei Chen, Binbin Huang
Abstract
Herein, we report an effective C–H bond activation-alkylation strategy for 2-iodobenzoyl protected cyclic amines at the N -α-position through a visible-light mediated 1,5-hydrogen atom transfer (HAT) process.
Topics & Concepts
ChemistryAlkylationHydrogen atomHydrogen bondVisible spectrumHydrogenAtom (system on chip)PhotochemistryStereochemistryOrganic chemistryMoleculeCatalysisGroup (periodic table)OptoelectronicsComputer sciencePhysicsEmbedded systemRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods