Isoishwarane synthase from <i>Streptomyces lincolnensis</i>
Houchao Xu, Jan Rinkel, Jeroen S. Dickschat
Abstract
The product of a terpene synthase from <italic>Streptomyces lincolnensis</italic> has been identified as the new natural product isoishwarane. The enzyme mechanism was studied by isotopic labelling experiments and site-directed mutagenesis.
Topics & Concepts
ChemistryStreptomycesNatural productATP synthaseTerpeneStereochemistryEnzymeLabellingMutagenesisBiochemistryMutantBacteriaGeneticsBiologyGenePlant biochemistry and biosynthesisMicrobial Natural Products and BiosynthesisNatural product bioactivities and synthesis