Design, synthesis and biological evaluation of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives as potential antitumor agents
Jianqing Zhang, Hehua Xiong, Feiyi Yang, Jie He, Ting Chen, Dongxue Fu, Pengwu Zheng, Qidong Tang
Topics & Concepts
BenzamideHeLaChemistryPyrimidineStereochemistryDocking (animal)IC50A549 cellStructure–activity relationshipCancer cell linesLead compoundCell cultureCombinatorial chemistryIn vitroCancer cellBiochemistryCancerBiologyNursingMedicineGeneticsQuinazolinone synthesis and applicationsBiochemical and Molecular ResearchCancer Mechanisms and Therapy