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Discovery of novel VEGFR-2-PROTAC degraders based on the localization of lysine residues via recruiting VHL for the treatment of gastric cancer

Xingrong Wang, Shuai Wang, Hong-Xia Mu, Kai-Yan Xu, Xueting Wang, Jian-Tao Shi, Qi-Hang Cui, Liwen Zhang, Shi‐Wu Chen

2022European Journal of Medicinal Chemistry19 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryProtein degradationProteasomeAngiogenesisCancer researchIn vitroUbiquitinCancer cellLysineApoptosisCancerBiochemistryAmino acidBiologyGeneGeneticsProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis
Discovery of novel VEGFR-2-PROTAC degraders based on the localization of lysine residues via recruiting VHL for the treatment of gastric cancer | Litcius