Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma
Jinqi You, Xinyi Yang, Jingjing Zhao, Hao Chen, Yan Tang, Dijun Ouyang, Yuanyuan Liu, Yan Wang, Songzuo Xie, Yuanyuan Chen, Jinghao Liao, Tong Xiang, Jian‐Chuan Xia, Chaopin Yang, Desheng Weng
Abstract
metformin treatment is an effective strategy to improve the efficacy of CAR-T cell therapy, potentially benefiting some relapsed HCC patients.
Topics & Concepts
Hepatocellular carcinomaPhenotypeCellComputational biologyBiologyCancer researchGeneticsGeneCAR-T cell therapy researchPancreatic function and diabetesImmune Cell Function and Interaction