Liver-expressed <i>Cd302</i> and <i>Cr1l</i> limit hepatitis C virus cross-species transmission to mice
Richard J. P. Brown, Birthe Tegtmeyer, Julie Sheldon, Tanvi Khera, Anggakusuma, Daniel Tödt, Gabrielle Vièyres, Romy Weller, Sebastian Joecks, Yudi Zhang, Svenja M. Sake, Dorothea Bankwitz, Kathrin Welsch, Corinne Ginkel, Michael Engelmann, Gisa Gerold, Eike Steinmann, Qinggong Yuan, Michael Ott, Florian W. R. Vondran, Thomas Krey, L.J. Stroh, Csaba Miskey, Zoltán Ivics, Vanessa Herder, Wolfgang Baumgärtner, Chris Lauber, Michael Seifert, Alexander W. Tarr, C. Patrick McClure, Glenn Randall, Yasmine Baktash, Alexander Ploß, Viet Loan Dao Thi, Eleftherios Michailidis, Mohsan Saeed, Lieven Verhoye, Philip Meuleman, Natascha Goedecke, Dagmar Wirth, Charles M. Rice, Thomas Pietschmann
Abstract
expression in human HCV entry factor transgenic mice increased hepatocyte permissiveness for an adapted HCV strain and dysregulated expression of metabolic process and host defense genes. These findings highlight human-mouse differences in liver-intrinsic antiviral immunity and facilitate the development of next-generation murine models for preclinical testing of HCV vaccine candidates.