Targeting JMJD6/PPARγ/GPX4 axis overcomes ferroptosis resistance and enhances therapeutic efficacy in hepatocellular carcinoma
Jie Li, Shengwei Mao, Shiguang Yang, Yunwei Lou, Xuhui Zhao, Jiafeng Chen, Yichao Bu, Bei Lv, Qing Shi, Yunjie Zhang, Xingxing Zhang, Zhijie Yu, Yuan Fang, Jinglin Xia
Topics & Concepts
DemethylaseGene knockdownBiologyCancer researchMediatorEpigeneticsHepatocellular carcinomaGPX4IntracellularLipid peroxidationSorafenibIn vitroCell biologyProgrammed cell deathGlutathioneApoptosisDownregulation and upregulationSignal transductionCarcinogenesisCell growthCellCell cultureRegulation of gene expressionDrug resistanceLiver cancerCell cycleHCCSGene expressionmicroRNACancer cellOxidative stressKinaseCancerFerroptosis and cancer prognosisRNA modifications and cancerCancer-related molecular mechanisms research