GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity
Jian Lü, Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Gui Hua Wang, Ben Yin Yuan, Si Jia Huang, Xiao Qi Liu, Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Z. Ruan, Bi Cheng Liu, Kun Ling
Abstract
These findings suggested that dysbiosis of gut microbiota-modulated GPR43 activation contributed to albuminuria in DN, which could be mediated by podocyte insulin resistance through the inhibition of AMPKα activity.
Topics & Concepts
PodocyteDiabetic nephropathyPodocinInsulin resistanceAMPKEndocrinologyInternal medicineAlbuminuriaBiologyGLUT4KidneyInsulinProtein kinase AMedicineCell biologyKinaseProteinuriaDiabetes Treatment and ManagementRenal Diseases and GlomerulopathiesPancreatic function and diabetes