Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury
Jian Zhang, Yingying Xie, Jushuai Ma, Kaiqiang Liu, Yunshu Ding, Yong Li, Xiaoyun Jiao, Xilei Xie, Xu Wang, Bo Tang
Abstract
Two fluorescent probes (QM-S and QM-Se) featuring AIE properties were developed. The increased intracellular hypobromous acid (HOBr) in cardiomyocytes during MIRI was revealed with these probes. It was also observed that MIRI might be alleviated by combating oxidative stress, as well as inhibiting inflammation and ferroptosis, which could mediate oxidative stress.
Topics & Concepts
Oxidative stressFluorescenceChemistryIntracellularMyocardial ischemiaBiophysicsReperfusion injuryIschemiaOxidative phosphorylationBiochemistryCardiologyMedicineBiologyPhysicsQuantum mechanicsNitric Oxide and Endothelin EffectsAdenosine and Purinergic SignalingCardiac Ischemia and Reperfusion