SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species
Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah van Tol, Paulina Soto, Christian S. Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David A. Jacques, Benhur Lee, Emma Sierecki, Yann Gambin
Abstract
assay. We pushed this comparative alignment of IRF-3 and NLRP12 homologs and show that the lack or presence of cognate cleavage motifs in IRF-3 and NLRP12 could contribute to the presentation of disease in cats and tigers, for example. Our findings provide an explanatory framework for indepth studies into the pathophysiology of COVID-19.
Topics & Concepts
ProteasesProteaseCleaveBiologyIRF3Innate immune systemViral replicationCleavage (geology)Cell biologyVirologyImmune systemVirusEnzymeBiochemistryImmunologyPaleontologyFracture (geology)SARS-CoV-2 and COVID-19 Researchinterferon and immune responsesInflammasome and immune disorders